Inhibitors and Inducers

For lead references, see e. g.

D. Drießen, F. Stuhldreier, A. Frank, H. Stark, S. Wesselborg, B. Stork, T. J. J. Müller,* Novel meriolin derivatives as rapid apoptosis inducers. Bioorg. Med. Chem. 2019, 27, 3463-3468.

M. Wucherer-Plietker, E. Merkul, T. J. J. Müller, C. Esdar, T. Knöchel, T. Heinrich, H.-P. Buchstaller, H. Greiner,* D. Dorsch, D. Finsinger, M. Calderini, D. Bruge, Discovery of Novel 7-Azaindoles as PDK1 Inhibitors. Bioorg. Med. Chem. Lett. 2016, 26, 3073-3080.

E. Merkul, F. Klukas, D. Dorsch, U. Grädler, H. E. Greiner, T. J. J. Müller,* Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling–TMS-deprotection–CuAAC sequence. Org. Biomol. Chem. 2011, 9, 5129-5136.